Posts Tagged ‘malaria’

Reading List for 2/17/10

February 17th, 2010

Today we’re reading about some exciting developments in dealing with insect-borne diseases, updates on the prevalence of blinding diseases in Africa, and the start of the UN’s annual conference with NGO’s focusing on global health.

Posing Proteins: First Chikungunya Vaccine Tested on Monkeys Successfully, Down to Earth

Mosquito Nose Transplants Help Fight Malaria, Catharine Paddock, Medical News Today

Bednets to Stop Leishmaniasis Spread, Smriti Mallapaty, SciDevNet

Blinding Infectious Disease is More Common in Malawi Than Anticipated, Paul Chinnock, TropIKA

Ghana: Krachiwura’s SOS Message to Govt, Samuel Agbewode, AllAfrica.com

UN’s Annual Conference with Civil Society Groups to Spotlight Global Health Issues, UN News Centre

Interview with Dr. Peter Hotez on the Leonard Lopate Show!

January 28th, 2010

Listen to Dr. Hotez’s interview on WNYC radio’s Leonard Lopate show to discuss hookworm, national security, and why investing in NTDs is a “best buy” in public health!

http://www.wnyc.org/shows/lopate/episodes/2010/01/28/segments/149041

GlaxoSmithKline Launches New “Innovation Strategy,” Includes NTDs

January 21st, 2010

In a speech given to the Council on Foreign Relations in New York today, GlaxoSmithKline (GSK) CEO Andrew Witty announced a list of new initiatives he is launching in an effort to demonstrate GSK’s role in helping control and prevent diseases that disproportionately affect the world’s most impoverished populations.

The list includes:

  1. ‘Open Lab’ established with $8m seed funding for new research
  2. 13,500 malaria compounds to be made freely available
  3. New collaborations to share intellectual property for neglected tropical diseases
  4. Pledge to create sustainable pricing model for world’s most advanced malaria candidate vaccine
  5. GSK African Malaria Partnership awards four new grants worth $2.5m

The “Open Lab” will be a research facility at GSK owned offices in Spain, open to up to 60 scientists from around the world.  The scientists will be part of a drug discovery team with $8 million being spent on research and development for new medicines for  diseases of the developing world.

In addition, GSK is also working with BIO Ventures for Global Health (BVGH) to create a “knowledge pool” for NTDs. GSK and BVGH have partned with  the Emory Institute for Drug Discovery (EIDD) to help further “open up knowledge, chemical libraries, and other assets in the search for new medicines for neglected tropical diseases.”

In order to create a sustainable  commitment for programs that support research for malaria and NTDs,  Witty also announced a pledge to price GSK’s experimental malaria vaccine at just 5% above cost. This pricing model is to cover the cost of the vaccine, and the small return from it will be reinvested into research and development for GSK’s second-generation malaria vaccines and other vaccines for neglected tropical diseases.  

“We are trying to set the expectation that there will be some return” for creating medicines for poor countries, he said in an interview with Forbes. “If we come out and say it is 0% profit” for the malaria vaccine, there would be no incentive for companies to invest in neglected disease research in the future.”

This is definitely a step in the right direction for the fight against NTDs!

If GSK is able to maintain a long-term, sustainable commitment to NTDs and Malaria, hopefully it will incentive other drug companies to follow suit.

Future Vaccine May Block the Bite of Malaria Transmitting Mosquitoes

January 15th, 2010

Mosquito

Mosquitoes are renowned for being pesky little insects that can leave you scratching your arms during the warm months, but for individuals residing in proximity to the Anopheles genus—the only species of mosquito which can transmit malaria—the bite of an infected mosquito is more than a nuisance and can be fatal if not promptly treated with the proper medication.

Each year nearly 900,000 people die of malaria, with the majority of deaths occurring in children under the age of five in Sub-Saharan Africa.  With this devastating toll in mind, researchers from the PATH Malaria Vaccine Initiative (MVI), Johns Hopkins Bloomberg School of Health and Sabin Vaccine Institute have formed a partnership to develop a novel vaccine—a “transmission blocking” vaccine that would stop the malaria parasite from developing in the mosquito, and thus, block the transmission of malaria from mosquitoes to humans.

Over the next 18 months, MVI, Johns Hopkins, and Sabin will collaborate to produce and characterize an antigen that can activate the body’s defenses to disrupt the complex human-mosquito transmission cycle of malaria. When an infected mosquito takes blood from a person vaccinated with the AnAPN1 vaccine—which field research indicates is capable of blocking transmission of the two deadliest malaria parasites, Plasmodium falciparum and P. vivax—antibodies in the humans’ blood will prevent the parasite from attaching to and invading the mosquito’s gut.

Learn More Here

Caucus Expansion Event a Success

October 28th, 2009

This afternoon’s event to launch the newly-expanded Congressional Malaria and NTDs caucus was a great success.  Representatives from a number of Congressional offices, as well as the NGO and policy communities, attended the briefing and heard from Amb. Mark Green, Kari Stoever, Dr. Christopher King, and Amb. Mark Dybul.  Each of the speakers stressed the importance–for policymakers, for American taxpayers, and for affected communities–of integrated NTD and malaria efforts, and displayed optimism for the prospects of improved cost-efficiency and measurable results.

Amb. Mark Dybul, Dr. Christopher King, Kari Stoever, and Amb. Mark Green Present at the Congressional Malaria and NTD Caucus Event

Amb. Mark Dybul, Dr. Christopher King, Kari Stoever, and Amb. Mark Green Present at the Congressional Malaria and NTD Caucus Event

As Mark Green noted, “Reps. Payne and Boozman certainly aren’t scoring huge political points at home for doing this [work with the Caucus]…so we should support them.”  And he’s right.  So again, the Global Network would like to extend our deepest thanks to the Caucus Co-Chairs for their leadership on the diseases and for their innovative approach to integrated global health.  Please free to call their offices and share your gratitude as well!

More photos from the event can be found at Malaria Policy Center’s Flickr page.  All photos are provided courtesy of Ben Brophy.

Mark Green: “We must integrate”

October 28th, 2009

mark_green_profileMark Green is the Managing Director of Malaria No More’s Malaria Policy Center in Washington, DC.  He has served as U.S. Ambassador to Tanzania and as a U.S. Congressman.

‘Malaria is deadly and yet we can prevent it with simple and affordable tools if we get them in the hands of the people that need them the most.’ That is a simple statement and it is one that I spend my days presenting. As the Managing Director of the Malaria Policy Center, my mandate is pretty clear, ‘advocate for an end to malaria deaths.’ But in Washington it can be all too easy to focus on a narrow interpretation of that mandate; after all this is a town where people establish careers by defending or championing just one issue. Today in the global health arena we don’t have that option. We must integrate work against a number of diseases to be the most effective and truly change our world.

I have spent a lot of time as a teacher and Ambassador in Africa and one thing I remember is that sick Africans don’t visit different clinics depending on their illness. There are not separate clinics for malaria and river blindness in the most remote of villages. If communities are lucky enough to have even one clinic it must respond to and treat any number of diseases. I think our approach to global health efforts must recognize this and find ways to combine efforts for the greatest impact.

Malaria and neglected tropical diseases (NTDs) are perfect examples of how we can pair efforts and they have seen success individually, showing us that we can realize improved health systems and an end to deaths from disease.

» Read more: Mark Green: “We must integrate”