Posts Tagged ‘deworming’

Reading List – 3/9/2010

March 9th, 2010

Hello everybody! Today we’re reading about GlaxoSmithKline upping its efforts to fight lymphatic filariasis, a new treatment for American soldiers who caught cutaneous leishmaniasis in Iraq, the latest release on the fight against LF in India, and, on a different note, a group of ultra-Orthodox rabbis declaring that lox should no longer be considered kosher due to a variant of roundworm found in fish.

In tough climate, GSK dedicates plant to fight elephantiasis, Rick Smith, Localtechwire

Heat therapy shown effective in treating cutaneous leishmaniasis among US soldiers in Iraq, PLoS Neglected Tropical Diseases

DMO allays fears over DEC tablets, The Hindu

Rabbis Claim Lox No Longer Kosher, Erica Butler, NBC New York

Studies Uncover Potential New Roundworm Treatment

March 2nd, 2010

Amongst all the parasitic NTDs, roundworm (Ascariasis) stands out in particular, primarily for how widespread it is. An estimated over 800 million people worldwide, about one-eighth the world’s population, are infected with roundworm, 200 million more than whipworm, the next most widespread NTD. On top of that, the people most at risk for contracting roundworm are children ages 3 to 5. Considering that roundworm causes malnutrition, anemia, and physical and mental underdevelopment in children, the burden of this parasite becomes painfully clear. There is a treatment for roundworm, albendazole, but the worm is beginning to show signs of resistance to it. Fortunately, a new paper published today indicates a possible new cure for roundworm.

This new cure is based off of crystal proteins created by the soil bacterium Bacillus thuringiensis (Bt). Bt has been used in agriculture for decades to kill insects and certain crops have been genetically modified with Bt to eliminate the need to use insecticide. However, their use as a medicine had gone largely untested, until couple of new studies show great promise that Bt could be an effective way to treat roundworm in humans.

The paper released today documents an experiment where mice were infected with roundworm and allowed to mature before the mice were treated with Bt. The effect was dramatic. Within just a few days there was a 98% decrease in parasite eggs in the mice’s feces and a 70% decrease in intestinal parasites.  This comes on the heels of a previous test where hamsters were infected with roundworm and treated with Bt. In that test the hamsters saw a 90% decrease in roundworm.

The most noteworthy quote came from Dr. Raffi Aroian from UC San Diego, the author of this paper. “Compared to the best drugs people have developed to treat human parasitic worms,” Dr Aroian said, “this natural protein is at least three times better.” Dr. Aroian also explained that since Bt is already grown in large quantities that currently treating one individual with Bt would cost 28 cents, a cost that would certainly go down with future optimization and development.

Just last week we highlighted a paper discussing the innovation gap that exists in the NTD field. Today’s paper shows that there are dedicated professionals currently working hard to bridge that gap.

Reading List 3/2/10

March 2nd, 2010

Here’s what we’re reading today:

Trachoma casts shadow over Aboriginal communities, Australian Broadcast Corporation

Chagas disease surveillance focuses on palms, undercover bugs, Beth King, Smithsonian Tropical Research Institute

ADRA and Guyanese Government Partner to Combat Parasitic Diseases, Nadia McGill, Reuters

Vote for Neglected Tropical Diseases!

March 2nd, 2010

The Global Network is a finalist in Kiwanis International’s quest for their next World Service Project. If Neglected Tropical Diseases (NTDs) are chosen, this could make a HUGE impact in the control and elimination of diseases that affect 1.4 billion people worldwide!

 The Global Network’s Proposal is to ensure that more than 1 billion children born between 2003 and 2020 journey into adulthood as the first generation to grow and thrive without the burden of NTDs.Ending the neglected of these diseases will help bring prosperity to local economies, increase access to education, reduce poverty and most importantly, build sustainable development.

 

Please join the discussion and vote for Neglected Tropical Diseases!

http://sites.kiwanis.org/Kiwanis/en/worldwide-service-project/wsp-idd/joindiscussion.aspx

Reading List – 2/22/10

February 22nd, 2010

Not much to read today, but there’s still some important stuff out there. Today we’re reading about an anti-lymphatic filariasis effort in Nepal and an update on the fight against Guinea worm.

Free drugs of Filariasis distributed in Kaski, The Rising Nepal

Carter: Eradication of Guinea Worm Disease Near in Sudan, Sheila Poole, Atlanta Journal-Constitution

Good Read: Ending the Neglect of Neglected Tropical Diseases

February 19th, 2010

Here is some worthwhile weekend reading! Perfect for lounging out and sipping a cup of tea at a local coffee shop!

 The Population Research Bureau (PRB) put out a policy brief called “Ending the Neglect of Neglected Tropical Diseases.” The paper gives a good introduction and breakdown of NTDs, its global impact and the cost-effective and efficient solutions available now to help tackle them.

Check it out here

Neglected Tropical Diseases and the Quest for Social Justice

February 19th, 2010

Tomorrow, February 20th, 2010, marks the second annual World Day of Social Justice. This event was created in 2007 to “consolidate further the efforts of the international community in poverty eradication and in promoting full employment and decent work, gender equality and access to social well-being and justice for all.” There are many ways to work towards those goals, but one of the most effective, and cost effective, is the elimination of neglected tropical diseases (NTDs).

 To eradicate poverty and promote full employment, NTD treatment is vital in the developing world. If a person is suffering from lymphatic filariasis and has severely swollen limbs to the point of being unable to work, or have contracted trachoma or onchocerciasis and gone blind, it hinders their ability to earn a living. Infections from the soil-transmitted helminth family of parasites cause anemia and nutrient deficiencies in children, stunting their physical and mental development. One of these parasites, roundworm, can decrease the future earnings potential of an infected child by 43%. However, deworming not only prevents the developmental disabilities created by infection, but also has been found to decrease school absenteeism by 25%. If future generations are to break free of the vicious cycle of poverty and unemployment, then NTD treatment must be included in any efforts.

Photo courtesy of Lindsay Wheeler

Photo courtesy of Lindsay Wheeler

 NTDs also play heavily into issues of gender equality, as they tend to disproportionately affect women. In areas of great gender inequality, the social stigmas attached to the disfigurement, morbidity, and disability caused by NTDs tend to be especially isolating and ostracizing for women. Women who have suffered from disfiguring NTDs such as lymphatic filariasis or onchoerciasis have lost their jobs, lost their families, and even been prevented from seeking medical attention. Further, NTDs pose special risks to women sexually and reproductively.  NTD infections cause women in particular to be especially at risk for sexually transmitted diseases. Genital sores on women caused by schistosomiasis have been shown to increase the risk of HIV infection threefold. Both schistosomiasis and roundworm have been linked to maternal anemia during pregnancy, leading to complications, as well as low birth weight and sterility. For gender equality to be reached, these diseases which disproportionately affect women must be dealt with.

 Those two points together make a strong case for NTD treatment, but there’s even more to be said in terms of social well-being and justice. Nations which are unstable or volatile, such as Pakistan, Niger, or Sudan, tend to have a high NTD disease burden. That is no coincidence. NTDs breed the poverty and inequality that give rise to political instability and violence. NTD treatment would not only heal the sick and help the poor, but it would help to stabilize nations and entire regions.

 So tomorrow, as you enjoy your Saturday, remember those less fortunate than you. Remember those for whom survival is a daily struggle, poverty an unavoidable fact of life, and political instability and violence an ever present threat. Then consider that treatment for the seven most common NTDs can be provided for only 50 cents a year per person. Consider all the good that can be done for such a small price.

 The UN created World Day of Social Justice with an eye towards a better future. For that to be accomplished, NTD treatment must be part of the plan.

The Global Fight Against Guinea Worm

February 5th, 2010

Surprisingly, modern science has thus far only successfully eradicated one disease—smallpox—but recent developments hint that the world is close to eradicating another devastating infection—Guinea worm. This parasite, which has plagued communities for centuries, causes painful wounds and has the potential to cause disability, infection, and death, but thanks to recent concentrated global efforts, Guinea worm may soon become the first parasitic disease to be eradicated.

 One very encouraging sign came last December when the World Health Organization (WHO) declared that Uganda had successfully eradicated Guinea worm within its borders. Uganda—which saw its last case of Guinea worm in 2003—joins seven other nations formally certified by the WHO as having eradicated the disease. Even more encouraging is the claim that in 2009 Nigeria experienced zero cases of Guinea worm. This makes Nigeria the 14th of 19 nations previously identified as endemic with the parasite to have recently eliminated the disease within its borders. Should Nigeria continue to be free of Guinea worm for the next several years, it will be WHO certified as having successfully eradicated the disease. Considering that Niger had only 3 cases of Guinea worm in 2009, it’s clear that the campaign to eradicate Guinea worm has been a great success thus far.

 And this success was the result of the combined work of the Carter Center, the United States Center for Disease Control, WHO, and UNICEF, as well as other organizations and individuals. With similar efforts, other parasitic worms, including those in the destructive soil-transmitted helminths family, could be controlled, and perhaps one day eradicated altogether.

Reading List 2/3/10

February 3rd, 2010

Today we’re reading about the fallout from Monday’s unveiling of the fiscal year 2011 budget and various analysis of how it will impact the global health sector and NTDs in particular. We’re also reading about other miscellaneous developments in NTDs and global health.

  1. Obama’s FY 2011 budget gives global health funding boost, Kaiser Family Foundation
    An article breaking down global health spending in the fiscal year 2011 budget.
  2. Aid advocates happy, not thrilled with Obama’s new budget, Josh Rogin, Foreign Policy
  3. Obama’s Global Health Budget a Mixed Bag, Te-Ping Chen, Change.org
    Two different analysis of the global health aspect of the 2011 budget.
  4. Glaxo CEO: Time to diversify, help poor countries, Associated Press
    An interview with the CEO of GlaxoSmithKlein about what the company is doing to help address global health.
  5. Nigeria moves towards eradication of Guinea worm, Azoma Chikwe, Daily Sun
    After decades of work, Nigeria is on the cusp of becoming another deworming success story.
  6. UNICEF And Partners Kick Off Fifth Annual Global Immunization Meeting, Medical News Today
    UNICEF, the WHO, and the GAVI Alliance are meeting in Geneva to analyze and improve immunization efforts globally

Reading List 1/19/2009

January 19th, 2010

Haiti

  1. Why Haiti Matters, Barack Obama, Newsweek.com
  2.  Ban Ki-Moon: What I saw in Haiti, New York Times
  3. US Troops Land at Haiti Presidential Palace, BBC News
  4. It became increasingly, brutally clear: Port-au-Prince is a tomb, The Guardian
  5. Need is great in Haiti’s orphanages, Contra Costa Times
  6. Haitians in the grip of lethal diseases, Press TV
  7. Medical correspondents face delicate balance in Haiti, LA Times
  8. Divided over Haiti, The Economist

NTDs/Global Health

  1. Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy framework, The Lancet
  2. The Unsung Hero of Neglected Tropical Diseases: Interview with Narcis Kabatereine, PLoS Neglected Tropical Diseases
  3. Socioeconomic aspects of neglected tropical diseases, The Lancet
  4. Beyond the Big Three, Andrew Sullivan, The Atlantic
  5. Progress Report of a Millennium Village, Nicholas Kristof, New York Times